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60-electrode thin mea chips  (Multi Channel Systems GmbH)
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Multi Channel Systems GmbH 60-electrode thin mea chips
60 Electrode Thin Mea Chips, supplied by Multi Channel Systems GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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standard 60-electrode meas (60mea200/30ir  (Mcs GmbH)
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Mcs GmbH standard 60-electrode meas (60mea200/30ir
Standard 60 Electrode Meas (60mea200/30ir, supplied by Mcs GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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meas containing 60 titanium nitride electrodes (diameter 30 µm, spacing 200 µm, impedance 50 kω at 1 khz)  (Mcs GmbH)
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Mcs GmbH meas containing 60 titanium nitride electrodes (diameter 30 µm, spacing 200 µm, impedance 50 kω at 1 khz)
(A) Coronal slice of a mouse brain depicting the recording <t>electrode</t> tract (green) as well as the outline of V1 and SC (dotted lines). (B, C) PSTH and spike raster plots of three example units in V1 ( B ) and SC ( C ) in response to visual, auditory and tactile stimulation (n trials =50). Each row shows the responses of one unit. Stimulus onset is depicted with a dashed line. (D, G) Average population responses of all units in rd10 (blue) and WT (gray) mice in SC ( D ) and V1 ( G ) to each stimulus presented (visual, tactile, auditory). Stimulus onset is marked by the dashed line. Responses were summed up for each session, baseline subtracted and then averaged. Shaded areas indicate the 95% confidence intervals. Boxplots show average population responses for each session (0-100 ms after stimulus onset). Statistical differences were compared using the Mann-Whitney U test (p<0.05) ( rd10 : n mice =4, n sessions =10, WT: n mice =3, n sessions =9). (E, H) Stimulus separability of single-units that responded to non-visual stimuli were measured using the AUC in rd10 (blue) and WT (gray) mice depicted as a boxplot and differences measured using Mann-Whitney U test (p≤0.05) ( rd10 : n mice =4, V1: n single-units =22, SC: n single-units =36, WT: n mice =3, V1: n single-units =39, SC: n single-units =61). (F, I) Fraction of single-units responsive to auditory or tactile stimulation in SC ( F ) and V1 (Ι) in rd10 (blue) as well as WT (gray) mice. In WT mice the fraction of single-units that also react to visual stimulation are marked as hatched. Errors are given as 95% confidence intervals as computed by asymptotic normal approximation, differences are compared using Fisher’s exact test (p≤0.05) ( rd10 : n mice =4, V1: non-visual: n single-units =22, SC: non-visual: n single-units =36, WT: n mice =3, V1: non-visual: n single-units =24, mixed: n single-units =15, SC: non-visual: n single-units =48, mixed: n single-units =13).
Meas Containing 60 Titanium Nitride Electrodes (Diameter 30 µm, Spacing 200 µm, Impedance 50 Kω At 1 Khz), supplied by Mcs GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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60-electrode meas with a 30 μm diameter and 500 μm electrode distance  (Mcs GmbH)
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Mcs GmbH 60-electrode meas with a 30 μm diameter and 500 μm electrode distance
(A) Coronal slice of a mouse brain depicting the recording <t>electrode</t> tract (green) as well as the outline of V1 and SC (dotted lines). (B, C) PSTH and spike raster plots of three example units in V1 ( B ) and SC ( C ) in response to visual, auditory and tactile stimulation (n trials =50). Each row shows the responses of one unit. Stimulus onset is depicted with a dashed line. (D, G) Average population responses of all units in rd10 (blue) and WT (gray) mice in SC ( D ) and V1 ( G ) to each stimulus presented (visual, tactile, auditory). Stimulus onset is marked by the dashed line. Responses were summed up for each session, baseline subtracted and then averaged. Shaded areas indicate the 95% confidence intervals. Boxplots show average population responses for each session (0-100 ms after stimulus onset). Statistical differences were compared using the Mann-Whitney U test (p<0.05) ( rd10 : n mice =4, n sessions =10, WT: n mice =3, n sessions =9). (E, H) Stimulus separability of single-units that responded to non-visual stimuli were measured using the AUC in rd10 (blue) and WT (gray) mice depicted as a boxplot and differences measured using Mann-Whitney U test (p≤0.05) ( rd10 : n mice =4, V1: n single-units =22, SC: n single-units =36, WT: n mice =3, V1: n single-units =39, SC: n single-units =61). (F, I) Fraction of single-units responsive to auditory or tactile stimulation in SC ( F ) and V1 (Ι) in rd10 (blue) as well as WT (gray) mice. In WT mice the fraction of single-units that also react to visual stimulation are marked as hatched. Errors are given as 95% confidence intervals as computed by asymptotic normal approximation, differences are compared using Fisher’s exact test (p≤0.05) ( rd10 : n mice =4, V1: non-visual: n single-units =22, SC: non-visual: n single-units =36, WT: n mice =3, V1: non-visual: n single-units =24, mixed: n single-units =15, SC: non-visual: n single-units =48, mixed: n single-units =13).
60 Electrode Meas With A 30 μm Diameter And 500 μm Electrode Distance, supplied by Mcs GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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60-electrode mea amplifier mea1060-upright  (Mcs GmbH)
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Mcs GmbH 60-electrode mea amplifier mea1060-upright
(A) Coronal slice of a mouse brain depicting the recording <t>electrode</t> tract (green) as well as the outline of V1 and SC (dotted lines). (B, C) PSTH and spike raster plots of three example units in V1 ( B ) and SC ( C ) in response to visual, auditory and tactile stimulation (n trials =50). Each row shows the responses of one unit. Stimulus onset is depicted with a dashed line. (D, G) Average population responses of all units in rd10 (blue) and WT (gray) mice in SC ( D ) and V1 ( G ) to each stimulus presented (visual, tactile, auditory). Stimulus onset is marked by the dashed line. Responses were summed up for each session, baseline subtracted and then averaged. Shaded areas indicate the 95% confidence intervals. Boxplots show average population responses for each session (0-100 ms after stimulus onset). Statistical differences were compared using the Mann-Whitney U test (p<0.05) ( rd10 : n mice =4, n sessions =10, WT: n mice =3, n sessions =9). (E, H) Stimulus separability of single-units that responded to non-visual stimuli were measured using the AUC in rd10 (blue) and WT (gray) mice depicted as a boxplot and differences measured using Mann-Whitney U test (p≤0.05) ( rd10 : n mice =4, V1: n single-units =22, SC: n single-units =36, WT: n mice =3, V1: n single-units =39, SC: n single-units =61). (F, I) Fraction of single-units responsive to auditory or tactile stimulation in SC ( F ) and V1 (Ι) in rd10 (blue) as well as WT (gray) mice. In WT mice the fraction of single-units that also react to visual stimulation are marked as hatched. Errors are given as 95% confidence intervals as computed by asymptotic normal approximation, differences are compared using Fisher’s exact test (p≤0.05) ( rd10 : n mice =4, V1: non-visual: n single-units =22, SC: non-visual: n single-units =36, WT: n mice =3, V1: non-visual: n single-units =24, mixed: n single-units =15, SC: non-visual: n single-units =48, mixed: n single-units =13).
60 Electrode Mea Amplifier Mea1060 Upright, supplied by Mcs GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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60-electrode perforated mea glass ring  (Mcs GmbH)
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Mcs GmbH 60-electrode perforated mea glass ring
(A) Coronal slice of a mouse brain depicting the recording <t>electrode</t> tract (green) as well as the outline of V1 and SC (dotted lines). (B, C) PSTH and spike raster plots of three example units in V1 ( B ) and SC ( C ) in response to visual, auditory and tactile stimulation (n trials =50). Each row shows the responses of one unit. Stimulus onset is depicted with a dashed line. (D, G) Average population responses of all units in rd10 (blue) and WT (gray) mice in SC ( D ) and V1 ( G ) to each stimulus presented (visual, tactile, auditory). Stimulus onset is marked by the dashed line. Responses were summed up for each session, baseline subtracted and then averaged. Shaded areas indicate the 95% confidence intervals. Boxplots show average population responses for each session (0-100 ms after stimulus onset). Statistical differences were compared using the Mann-Whitney U test (p<0.05) ( rd10 : n mice =4, n sessions =10, WT: n mice =3, n sessions =9). (E, H) Stimulus separability of single-units that responded to non-visual stimuli were measured using the AUC in rd10 (blue) and WT (gray) mice depicted as a boxplot and differences measured using Mann-Whitney U test (p≤0.05) ( rd10 : n mice =4, V1: n single-units =22, SC: n single-units =36, WT: n mice =3, V1: n single-units =39, SC: n single-units =61). (F, I) Fraction of single-units responsive to auditory or tactile stimulation in SC ( F ) and V1 (Ι) in rd10 (blue) as well as WT (gray) mice. In WT mice the fraction of single-units that also react to visual stimulation are marked as hatched. Errors are given as 95% confidence intervals as computed by asymptotic normal approximation, differences are compared using Fisher’s exact test (p≤0.05) ( rd10 : n mice =4, V1: non-visual: n single-units =22, SC: non-visual: n single-units =36, WT: n mice =3, V1: non-visual: n single-units =24, mixed: n single-units =15, SC: non-visual: n single-units =48, mixed: n single-units =13).
60 Electrode Perforated Mea Glass Ring, supplied by Mcs GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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meas (60 electrodes terminals) 60ecomea-glass-gr  (Mcs GmbH)
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Mcs GmbH meas (60 electrodes terminals) 60ecomea-glass-gr
(A) Coronal slice of a mouse brain depicting the recording <t>electrode</t> tract (green) as well as the outline of V1 and SC (dotted lines). (B, C) PSTH and spike raster plots of three example units in V1 ( B ) and SC ( C ) in response to visual, auditory and tactile stimulation (n trials =50). Each row shows the responses of one unit. Stimulus onset is depicted with a dashed line. (D, G) Average population responses of all units in rd10 (blue) and WT (gray) mice in SC ( D ) and V1 ( G ) to each stimulus presented (visual, tactile, auditory). Stimulus onset is marked by the dashed line. Responses were summed up for each session, baseline subtracted and then averaged. Shaded areas indicate the 95% confidence intervals. Boxplots show average population responses for each session (0-100 ms after stimulus onset). Statistical differences were compared using the Mann-Whitney U test (p<0.05) ( rd10 : n mice =4, n sessions =10, WT: n mice =3, n sessions =9). (E, H) Stimulus separability of single-units that responded to non-visual stimuli were measured using the AUC in rd10 (blue) and WT (gray) mice depicted as a boxplot and differences measured using Mann-Whitney U test (p≤0.05) ( rd10 : n mice =4, V1: n single-units =22, SC: n single-units =36, WT: n mice =3, V1: n single-units =39, SC: n single-units =61). (F, I) Fraction of single-units responsive to auditory or tactile stimulation in SC ( F ) and V1 (Ι) in rd10 (blue) as well as WT (gray) mice. In WT mice the fraction of single-units that also react to visual stimulation are marked as hatched. Errors are given as 95% confidence intervals as computed by asymptotic normal approximation, differences are compared using Fisher’s exact test (p≤0.05) ( rd10 : n mice =4, V1: non-visual: n single-units =22, SC: non-visual: n single-units =36, WT: n mice =3, V1: non-visual: n single-units =24, mixed: n single-units =15, SC: non-visual: n single-units =48, mixed: n single-units =13).
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3d-mea chip with 60 tip-shaped and 60-μm-high electrodes spaced by 100 μm  (Ayanda GmbH)
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Ayanda GmbH 3d-mea chip with 60 tip-shaped and 60-μm-high electrodes spaced by 100 μm
(A) Coronal slice of a mouse brain depicting the recording <t>electrode</t> tract (green) as well as the outline of V1 and SC (dotted lines). (B, C) PSTH and spike raster plots of three example units in V1 ( B ) and SC ( C ) in response to visual, auditory and tactile stimulation (n trials =50). Each row shows the responses of one unit. Stimulus onset is depicted with a dashed line. (D, G) Average population responses of all units in rd10 (blue) and WT (gray) mice in SC ( D ) and V1 ( G ) to each stimulus presented (visual, tactile, auditory). Stimulus onset is marked by the dashed line. Responses were summed up for each session, baseline subtracted and then averaged. Shaded areas indicate the 95% confidence intervals. Boxplots show average population responses for each session (0-100 ms after stimulus onset). Statistical differences were compared using the Mann-Whitney U test (p<0.05) ( rd10 : n mice =4, n sessions =10, WT: n mice =3, n sessions =9). (E, H) Stimulus separability of single-units that responded to non-visual stimuli were measured using the AUC in rd10 (blue) and WT (gray) mice depicted as a boxplot and differences measured using Mann-Whitney U test (p≤0.05) ( rd10 : n mice =4, V1: n single-units =22, SC: n single-units =36, WT: n mice =3, V1: n single-units =39, SC: n single-units =61). (F, I) Fraction of single-units responsive to auditory or tactile stimulation in SC ( F ) and V1 (Ι) in rd10 (blue) as well as WT (gray) mice. In WT mice the fraction of single-units that also react to visual stimulation are marked as hatched. Errors are given as 95% confidence intervals as computed by asymptotic normal approximation, differences are compared using Fisher’s exact test (p≤0.05) ( rd10 : n mice =4, V1: non-visual: n single-units =22, SC: non-visual: n single-units =36, WT: n mice =3, V1: non-visual: n single-units =24, mixed: n single-units =15, SC: non-visual: n single-units =48, mixed: n single-units =13).
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meas containing 60 titanium nitride electrodes  (Mcs GmbH)
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Mcs GmbH meas containing 60 titanium nitride electrodes
Spontaneous activity of different RGCs in rd10 retina. ( A – Ci ) Raw data of MEA recordings at different <t>electrodes.</t> ( A – Cii ) High-pass filtered to show the APs. ( A – Ciii ) Low-pass filtered to isolate the LFP. ( A – Civ ) Frequency analysis of the oscillations using Fast Fourier Transformation. In most of the recordings, oscillations could be observed at a frequency of approximately 3 Hz ( Aiv + Biv ), but in some cases no oscillations ( Ciii ) or dominant frequency were observed ( Civ ). The age of the rd10 mouse was 3.5 months.
Meas Containing 60 Titanium Nitride Electrodes, supplied by Mcs GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


(A) Coronal slice of a mouse brain depicting the recording electrode tract (green) as well as the outline of V1 and SC (dotted lines). (B, C) PSTH and spike raster plots of three example units in V1 ( B ) and SC ( C ) in response to visual, auditory and tactile stimulation (n trials =50). Each row shows the responses of one unit. Stimulus onset is depicted with a dashed line. (D, G) Average population responses of all units in rd10 (blue) and WT (gray) mice in SC ( D ) and V1 ( G ) to each stimulus presented (visual, tactile, auditory). Stimulus onset is marked by the dashed line. Responses were summed up for each session, baseline subtracted and then averaged. Shaded areas indicate the 95% confidence intervals. Boxplots show average population responses for each session (0-100 ms after stimulus onset). Statistical differences were compared using the Mann-Whitney U test (p<0.05) ( rd10 : n mice =4, n sessions =10, WT: n mice =3, n sessions =9). (E, H) Stimulus separability of single-units that responded to non-visual stimuli were measured using the AUC in rd10 (blue) and WT (gray) mice depicted as a boxplot and differences measured using Mann-Whitney U test (p≤0.05) ( rd10 : n mice =4, V1: n single-units =22, SC: n single-units =36, WT: n mice =3, V1: n single-units =39, SC: n single-units =61). (F, I) Fraction of single-units responsive to auditory or tactile stimulation in SC ( F ) and V1 (Ι) in rd10 (blue) as well as WT (gray) mice. In WT mice the fraction of single-units that also react to visual stimulation are marked as hatched. Errors are given as 95% confidence intervals as computed by asymptotic normal approximation, differences are compared using Fisher’s exact test (p≤0.05) ( rd10 : n mice =4, V1: non-visual: n single-units =22, SC: non-visual: n single-units =36, WT: n mice =3, V1: non-visual: n single-units =24, mixed: n single-units =15, SC: non-visual: n single-units =48, mixed: n single-units =13).

Journal: bioRxiv

Article Title: Ongoing activation of visual cortex and superior colliculus in the rd10 mouse model of retinitis pigmentosa

doi: 10.1101/2024.09.02.610761

Figure Lengend Snippet: (A) Coronal slice of a mouse brain depicting the recording electrode tract (green) as well as the outline of V1 and SC (dotted lines). (B, C) PSTH and spike raster plots of three example units in V1 ( B ) and SC ( C ) in response to visual, auditory and tactile stimulation (n trials =50). Each row shows the responses of one unit. Stimulus onset is depicted with a dashed line. (D, G) Average population responses of all units in rd10 (blue) and WT (gray) mice in SC ( D ) and V1 ( G ) to each stimulus presented (visual, tactile, auditory). Stimulus onset is marked by the dashed line. Responses were summed up for each session, baseline subtracted and then averaged. Shaded areas indicate the 95% confidence intervals. Boxplots show average population responses for each session (0-100 ms after stimulus onset). Statistical differences were compared using the Mann-Whitney U test (p<0.05) ( rd10 : n mice =4, n sessions =10, WT: n mice =3, n sessions =9). (E, H) Stimulus separability of single-units that responded to non-visual stimuli were measured using the AUC in rd10 (blue) and WT (gray) mice depicted as a boxplot and differences measured using Mann-Whitney U test (p≤0.05) ( rd10 : n mice =4, V1: n single-units =22, SC: n single-units =36, WT: n mice =3, V1: n single-units =39, SC: n single-units =61). (F, I) Fraction of single-units responsive to auditory or tactile stimulation in SC ( F ) and V1 (Ι) in rd10 (blue) as well as WT (gray) mice. In WT mice the fraction of single-units that also react to visual stimulation are marked as hatched. Errors are given as 95% confidence intervals as computed by asymptotic normal approximation, differences are compared using Fisher’s exact test (p≤0.05) ( rd10 : n mice =4, V1: non-visual: n single-units =22, SC: non-visual: n single-units =36, WT: n mice =3, V1: non-visual: n single-units =24, mixed: n single-units =15, SC: non-visual: n single-units =48, mixed: n single-units =13).

Article Snippet: MEAs containing 60 titanium nitride electrodes (diameter 30 µm, spacing 200 µm, impedance 50 kΩ at 1 kHz) on a glass substrate (Multi Channel Systems MCS GmbH, Reutlingen, Germany) were used.

Techniques: MANN-WHITNEY

Spontaneous activity of different RGCs in rd10 retina. ( A – Ci ) Raw data of MEA recordings at different electrodes. ( A – Cii ) High-pass filtered to show the APs. ( A – Ciii ) Low-pass filtered to isolate the LFP. ( A – Civ ) Frequency analysis of the oscillations using Fast Fourier Transformation. In most of the recordings, oscillations could be observed at a frequency of approximately 3 Hz ( Aiv + Biv ), but in some cases no oscillations ( Ciii ) or dominant frequency were observed ( Civ ). The age of the rd10 mouse was 3.5 months.

Journal: Investigative Ophthalmology & Visual Science

Article Title: Blockade of Retinal Oscillations by Benzodiazepines Improves Efficiency of Electrical Stimulation in the Mouse Model of RP, rd10

doi: 10.1167/iovs.61.13.37

Figure Lengend Snippet: Spontaneous activity of different RGCs in rd10 retina. ( A – Ci ) Raw data of MEA recordings at different electrodes. ( A – Cii ) High-pass filtered to show the APs. ( A – Ciii ) Low-pass filtered to isolate the LFP. ( A – Civ ) Frequency analysis of the oscillations using Fast Fourier Transformation. In most of the recordings, oscillations could be observed at a frequency of approximately 3 Hz ( Aiv + Biv ), but in some cases no oscillations ( Ciii ) or dominant frequency were observed ( Civ ). The age of the rd10 mouse was 3.5 months.

Article Snippet: MEAs containing 60 titanium nitride electrodes (diameter 30 μm, spacing 200 μm, impedance 50 kΩ at 1 kHz) on a glass substrate (Multi Channel Systems MCS GmbH, Reutlingen, Germany) were used.

Techniques: Activity Assay, Transformation Assay

Effect of the inhibitory neurotransmitters glycine and GABA on rhythmic electrical activity in rd10 retina. ( A , D ) Recording under control condition (unfiltered raw data) displayed oscillations in the LFP. ( B ) Application of 100 µM glycine for 7 minutes nearly abolished oscillations. Oscillations were also abolished by 40 µM glycine; however, a wash-in time of 20 to 30 minutes was required (data not shown). ( C ) The effect was reversible during wash-out (10 minutes). ( E ) Application of 500 µM GABA for 5 minutes completely abolished oscillations. With 100 µM GABA (data not shown), oscillations vanished on most electrodes and amplitudes of oscillations were decreased on remaining electrodes after wash-in time of 20 to 30 minutes. ( F ) The effect was reversible during wash-out. The age of the rd10 mice was 3.5 months.

Journal: Investigative Ophthalmology & Visual Science

Article Title: Blockade of Retinal Oscillations by Benzodiazepines Improves Efficiency of Electrical Stimulation in the Mouse Model of RP, rd10

doi: 10.1167/iovs.61.13.37

Figure Lengend Snippet: Effect of the inhibitory neurotransmitters glycine and GABA on rhythmic electrical activity in rd10 retina. ( A , D ) Recording under control condition (unfiltered raw data) displayed oscillations in the LFP. ( B ) Application of 100 µM glycine for 7 minutes nearly abolished oscillations. Oscillations were also abolished by 40 µM glycine; however, a wash-in time of 20 to 30 minutes was required (data not shown). ( C ) The effect was reversible during wash-out (10 minutes). ( E ) Application of 500 µM GABA for 5 minutes completely abolished oscillations. With 100 µM GABA (data not shown), oscillations vanished on most electrodes and amplitudes of oscillations were decreased on remaining electrodes after wash-in time of 20 to 30 minutes. ( F ) The effect was reversible during wash-out. The age of the rd10 mice was 3.5 months.

Article Snippet: MEAs containing 60 titanium nitride electrodes (diameter 30 μm, spacing 200 μm, impedance 50 kΩ at 1 kHz) on a glass substrate (Multi Channel Systems MCS GmbH, Reutlingen, Germany) were used.

Techniques: Activity Assay, Control